Package: nlmixr2scm
Title: Stepwise Covariate Modeling for 'nlmixr2' Models
Version: 0.4
Authors@R: c(
    person("Justin", "Wilkins", email = "justin.wilkins@occams.com", role = c("aut", "cre", "cph"),
           comment = c(ORCID = "0000-0002-7099-9396")),
    person("Matthew", "Fidler", email = "matthew.fidler@gmail.com", role = "aut",
           comment = c(ORCID = "0000-0001-8538-6691")),
    person("Yaping", "Liu", email = "ypliu@umich.edu", role = "aut",
           comment = c(ORCID = "0009-0009-2842-3797")),
    person("Bill", "Denney", email = "wdenney@humanpredictions.com", role = "aut",
           comment = c(ORCID = "0000-0002-5759-428X")),
    person("Vipul", "Mann", email = "vm2583@columbia.edu", role = "aut"),
    person("Vishal", "Sarsani", email = "vsarsani@umass.edu", role = "aut",
           comment = c(ORCID = "0000-0002-9272-3438")),
    person("Christian", "Bartels", email = "christian.bartels@novartis.com", role = "ctb")
  )
Description: Stepwise covariate modeling (SCM) for nonlinear mixed-effects
    models fitted with 'nlmixr2'. Forward inclusion and backward elimination
    are driven by likelihood-ratio tests, and the covariate terms are
    generated inside the model body, so continuous covariates are centered
    and categorical covariates expanded into indicator columns without
    editing the model by hand. Candidate fits can be cached and resumed,
    fitted in parallel, and reviewed through per-step and all-candidate
    summary tables. The approach follows Jonsson and Karlsson (1998)
    <doi:10.1023/A:1011970125687>, and the implementation in
    'Perl-speaks-NONMEM' described by Lindbom, Ribbing and Jonsson (2004)
    <doi:10.1016/j.cmpb.2003.11.003>.
Depends: R (>= 4.1)
License: GPL (>= 3)
URL: https://github.com/nlmixr2/nlmixr2scm
BugReports: https://github.com/nlmixr2/nlmixr2scm/issues
Imports: checkmate, cli (>= 3.4.0), data.table, lotri, nlme, nlmixr2est
        (>= 7.0.0), nlmixr2utils (>= 0.3), rxode2 (>= 5.0.0), stats,
        tools, utils
Suggests: future, knitr, nlmixr2data, pkgload, rmarkdown, testthat (>=
        3.0.0), withr
VignetteBuilder: knitr
Config/testthat/edition: 3
Encoding: UTF-8
Config/roxygen2/version: 8.1.0
NeedsCompilation: no
Packaged: 2026-09-14 09:38:51 UTC; justin
Author: Justin Wilkins [aut, cre, cph] (ORCID:
    <https://orcid.org/0000-0002-7099-9396>),
  Matthew Fidler [aut] (ORCID: <https://orcid.org/0000-0001-8538-6691>),
  Yaping Liu [aut] (ORCID: <https://orcid.org/0009-0009-2842-3797>),
  Bill Denney [aut] (ORCID: <https://orcid.org/0000-0002-5759-428X>),
  Vipul Mann [aut],
  Vishal Sarsani [aut] (ORCID: <https://orcid.org/0000-0002-9272-3438>),
  Christian Bartels [ctb]
Maintainer: Justin Wilkins <justin.wilkins@occams.com>
Repository: CRAN
Date/Publication: 2026-09-24 13:30:14 UTC
