Package: httkexamples
Version: 0.0.1
Date: 2025-12-03
Title: High-Throughput Toxicokinetics Examples
Description: High throughput toxicokinetics ("HTTK") is the 
             combination of 1) chemical-specific in vitro measurements or in
             silico predictions and 2) generic mathematical models, to
             predict absorption, distribution, metabolism, and excretion by the
             body. HTTK methods have been described by Pearce et al. (2017) 
             (<doi:10.18637/jss.v079.i04>) and Breen et al. (2021) (<doi:10.1080/17425255.2021.1935867>).
             Here we provide examples (vignettes) applying HTTK to solve various
             problems in bioinformatics, toxicology, and exposure science.
             In accordance with Davidson-Fritz et al. (2025) (<doi:10.1371/journal.pone.0321321>),
             whenever a new HTTK model is developed, the code to generate the 
             figures evaluating that model is added as a new vignettte.  
Authors@R: c(
           person("John", "Wambaugh", email = "john.wambaugh@UL.org", 
             role = c("aut", "cre"),
             comment = c(ORCID = "0000-0002-4024-534X")), 
           person("Robert", "Pearce", role = c("aut"),
             comment = c(ORCID = "0000-0003-3168-4049")), 
           person("Caroline", "Ring", email = "Ring.Caroline@epa.gov", 
             role = c("aut"), comment = c(ORCID = "0000-0002-0463-1251")), 
           person("Greg", "Honda", email = "honda.gregory@epa.gov", 
             role = c("aut"), comment = c(ORCID = "0000-0001-7713-9850")), 
           person("Matt", "Linakis", email = "MLINAKIS@ramboll.com", 
             role = c("aut"), comment = c(ORCID = "0000-0003-0526-2395")), 
           person("Dustin", "Kapraun", email = "kapraun.dustin@epa.gov",
             role = c("aut"), comment = c(ORCID= "0000-0001-5570-6383")),
           person("Kimberly", "Truong", email = "truong.kimberly@epa.gov", 
             role = c("aut"), comment = c(ORCID = "0000-0003-1716-1006")), 
           person("Meredith", "Scherer", email="Scherer.Meredith@epa.gov",
             role = c("aut"), comment = c(ORCID = "0000-0002-9785-7363")),
           person("Annabel", "Meade", email = "aemeade7@gmail.com",
             role = c("aut"), comment = c(ORCID = "0000-0002-5452-8797")),
           person("Celia", "Schacht", email="Schacht.Celia@epa.gov",
             role = c("aut"), comment = c(ORCID = "0000-0002-8131-513X")),
           person("Elaina", "Kenyon",
             role = c("ctb"), comment = c(ORCID = "0000-0001-8781-2391"))
           )
Depends: R (>= 2.10)
Imports: httk, rmarkdown, knitr, Rdpack
RdMacros: Rdpack
Suggests: dplyr, tidyverse, xlsx, Metrics, ggplot2, ggforce, ggpubr,
        ggrepel, viridis, ggpubr, grid, ggh4x, readr, ggforce, tidyr,
        stringr, pracma, cgwtools, openxlsx, ggstar, latex2exp, smatr,
        reshape,
        gdata,censReg,gmodels,gplots,scales,colorspace,gridExtra,
        rvcheck
License: MIT + file LICENSE
LazyData: true
LazyDataCompression: xz
Encoding: UTF-8
VignetteBuilder: knitr
RoxygenNote: 7.3.3
URL: https://chemicalinsights.ul.org/
NeedsCompilation: no
Packaged: 2025-12-04 00:56:11 UTC; WambaughJohn
Author: John Wambaugh [aut, cre] (ORCID:
    <https://orcid.org/0000-0002-4024-534X>),
  Robert Pearce [aut] (ORCID: <https://orcid.org/0000-0003-3168-4049>),
  Caroline Ring [aut] (ORCID: <https://orcid.org/0000-0002-0463-1251>),
  Greg Honda [aut] (ORCID: <https://orcid.org/0000-0001-7713-9850>),
  Matt Linakis [aut] (ORCID: <https://orcid.org/0000-0003-0526-2395>),
  Dustin Kapraun [aut] (ORCID: <https://orcid.org/0000-0001-5570-6383>),
  Kimberly Truong [aut] (ORCID: <https://orcid.org/0000-0003-1716-1006>),
  Meredith Scherer [aut] (ORCID: <https://orcid.org/0000-0002-9785-7363>),
  Annabel Meade [aut] (ORCID: <https://orcid.org/0000-0002-5452-8797>),
  Celia Schacht [aut] (ORCID: <https://orcid.org/0000-0002-8131-513X>),
  Elaina Kenyon [ctb] (ORCID: <https://orcid.org/0000-0001-8781-2391>)
Maintainer: John Wambaugh <john.wambaugh@UL.org>
Repository: CRAN
Date/Publication: 2025-12-10 21:00:02 UTC
Built: R 4.6.1; ; 2026-07-30 03:48:47 UTC; windows
