Pharmacometric Modeling

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Documentation for package ‘Certara.RsNLME’ version 3.2.0

• DESCRIPTION file.

Help Pages

addADDL	Adds ADDL extra column definition to model object
addCovariate	Add covariate to model object
addDoseCycle	Adds a dosing cycle to model
addExtraDef	Adds user defined extra column/table definitions to column definition file
addInfusion	Change existing dosing compartment to infusion
addLabel	Add levels and labels to categorical or occasion covariate
addMDV	Adds MDV extra column definition to model object
addReset	Adds reset instructions to the model
addReset-method	Adds reset instructions to the model
addSecondary	Adds a secondary parameter to model definition
addSecondary-method	Adds a secondary parameter to model definition
addSteadyState	Adds Steady State extra column definition to model object
bootstrap	Executes an NLME Bootstrap
cancelJob	Generic function for cancelling a job
cancelJob-method	Generic function for cancelling a job
collectJob	Collect the typed result of a finished NLME job
collectJob-method	Collect the typed result of a finished NLME job
colMapping	Add column mappings
copyModel	Copy model object to iterate over base model
covariateNames	Return covariate names
createModelInfo	Parse the model and get the list of terms
dataMapping	Initialize input data for PK/PD model
doseNames	Return dose names
editModel	Directly edit PML text in model object
emaxmodel	Create an Emax or Imax model
engineParams	Main function to specify engine parameters
extraDoseLines	Return extra dose lines
extraDoseNames	Return extra dose names
fitmodel	Executes an NLME simple estimation
getRandomEffectNames	Return random effect names in model
getSCMResults	Retrieve model and fitmodel-style results for a selected covariate search scenario.
getThetas	Return theta names and values
hostParams	Create an NLME Parallel Host Configuration
imputeMissingCovariates	Impute missing covariate values
imputeMode	Modal value with deterministic tie-break (default categorical aggregator)
initFixedEffects	Display/Set initial estimates for fixed effects
initFixedEffects-method	Display/Set initial estimates for fixed effects
initFixedEffects<-	Display/Set initial estimates for fixed effects
initFixedEffects<--method	Display/Set initial estimates for fixed effects
isPopulation	Get or set whether a model is a population model
isPopulation-method	Get or set whether a model is a population model
isPopulation<-	Get or set whether a model is a population model
isPopulation<--method	Get or set whether a model is a population model
linearmodel	Create linear model
listCovariateEffectNames	Lists covariate effect names in the model
listCovariateEffectNames-method	Lists covariate effect names in the model
listSCMRuns	List archived covariate search scenarios.
modelVariableNames	Return model variable names
obtain_NLMELicense	Obtain NLME License
OneCpt_IVInfusionData	Pharmacokinetic dataset containing 100 subjects with single dose given by infusion
parsePMLColMap	Embed column definition info into the model
pkcovbqlData	Pharmacokinetic pediatric dataset containing 80 subjects with single bolus dose.
pkData	Pharmacokinetic dataset containing 16 subjects with single bolus dose
pkemaxmodel	Create a PK/Emax or PK/Imax model
pkindirectmodel	Create a PK/Indirect response model
pklinearmodel	Create PK linear model
pkmodel	Creates a PK model
pkpdData	Pharmacokinetic/Pharmacodynamic dataset containing 200 subjects with single bolus dose
print.NlmePmlModel	Print generic for class NlmePmlModel
randomEffect	Sets or updates the covariance matrix of random effects
read_mmdl	Read a metamodel file (.mmdl)
removeCovariate	Remove covariate from structural parameters in a model object.
remove_NLMELicense	Remove NLME License
residualEffectNames	Return residual effect terms available in model
scmSearchTable	Presentation table for SCM search results
secondaryParameterNames	Get secondary parameter names
shotgunSearch	Executes an NLME shotgun covariate search
simmodel	Executes an NLME simulation
sortfit	Executes an NLME simple estimation with sort keys and given scenarios
stepwiseSearch	Executes an NLME stepwise covariate search
structuralParameter	Set structural parameter in model object
structuralParameterNames	Get structural parameter names
tableParams	Wrapper around NlmeTableDef/NlmeSimTableDef-classes initializers.
textualmodel	Create a textual model object
update_Omegas	Update omega (random-effect) initial values and freeze status
update_Sigmas	Update residual-error (sigma) initial values and freeze status
update_Thetas	Update fixed-effect (theta) initial values, bounds, freeze, and enable
vpcmodel	Perform visual predictive check for NLME models
write_mmdl	Write a metamodel file (.mmdl)