Package: RAS
Title: Regional Association Score for Genome-Wide Association Studies
Version: 1.1.2
Authors@R: c(
    person("Jiahe", "Jin", email = "jiahe.jin@yale.edu", role = "aut"),
    person("Yiran", "Jiang", email = "yiran.jiang@uky.edu", role = "aut"),
    person("Heping", "Zhang", email = "heping.zhang@yale.edu", role = c("aut", "cre")))
Description: Implements the Regional Association Score (RAS) method for
    genome-wide association studies (GWAS). For each single nucleotide
    polymorphism (SNP), RAS quantifies the strength of association within its
    surrounding genomic region, arranges these regional scores along the
    chromosome into a signal profile, and locates association regions on that
    profile with one of two detectors: the original changepoint detector, or a
    box-scan region detector that also delimits broad plateau-shaped regions.
    Genotypes can be streamed from a chunked on-disk format through compiled
    code so that peak memory no longer grows with chromosome size, and the
    regional weights can be taken from an independent external GWAS
    (harmonised summary statistics) instead of a within-sample split. The
    method is described in Jiang and Zhang (2025) <doi:10.1073/pnas.2419721122>.
License: MIT + file LICENSE
URL: https://github.com/hepingzhangyale/RAS
BugReports: https://github.com/hepingzhangyale/RAS/issues
Encoding: UTF-8
Language: en-GB
Imports: grDevices, graphics, parallel, segmented, stats, tools, utils
Suggests: testthat (>= 3.0.0)
Config/testthat/edition: 3
Config/roxygen2/version: 8.1.0
NeedsCompilation: yes
Packaged: 2026-09-26 13:23:55 UTC; ianji
Author: Jiahe Jin [aut],
  Yiran Jiang [aut],
  Heping Zhang [aut, cre]
Maintainer: Heping Zhang <heping.zhang@yale.edu>
Repository: CRAN
Date/Publication: 2026-09-26 22:10:02 UTC
Built: R 4.5.2; aarch64-apple-darwin20; 2026-09-27 00:44:58 UTC; unix
Archs: RAS.so.dSYM
